Brain tissue ammonia and Alzheimer type 2 astrocytosis in human liver cirrhosis
| dc.contributor.author | Shuliatnikova, T. V. | |
| dc.contributor.author | Tumanskyi, V. O. | |
| dc.contributor.author | Шулятнікова, Тетяна Володимирівна | |
| dc.contributor.author | Туманський, Валерій Олексійович | |
| dc.date.accessioned | 2023-06-15T11:26:37Z | |
| dc.date.available | 2023-06-15T11:26:37Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Hepatic encephalopathy (HE) is among key manifestations of decompensated liver cirrhosis (LC) and is typical for 30-45% of patients [1], reducing their survival rate up to 2 years. The neurotoxic effect of ammonia is central in the pathophysiology of HE [2]. In astrocytes, high ammonia concentration with glutamate are metabolized in osmotically active glutamine, accumulation of which causes astrocytes swelling and subsequent generalized brain edema [3]. | uk_UK |
| dc.identifier.citation | Shuliatnikova T. V. Brain tissue ammonia and Alzheimer type 2 astrocytosis in human liver cirrhosis / T. Shuliatnikova, V. Tumanskyi // Theory and practice of modern science : collection of scientific papers "SCIENTIA" with Proceedings of the V International Scientific andTheoretical Conference, May 12, 2023. Kraków, Republic of Poland. - Kraków : European Scientific Platform, 2023. - P. 161-162. | uk_UK |
| dc.identifier.uri | https://zsmu.rosbai.com/handle/123456789/18951 | |
| dc.language.iso | en | uk_UK |
| dc.subject | тези доповідей | uk_UK |
| dc.title | Brain tissue ammonia and Alzheimer type 2 astrocytosis in human liver cirrhosis | uk_UK |
| dc.type | Article | uk_UK |