Oxidative stress markers in women with pregnancy course complicated by miscarriage

Abstract

Long activation of free-radical oxidation processes is the base of pathogenesis of different pathological conditions. Besides the connection between nature of pathological process and changes of markers of organism protective antioxidant system is found [1]. Oxidative stress can have destructive influence on cellular structures of placenta. During investigation of placenta tissues it was found that in case of complicated pregnancy course (threatening miscarriage, gestosis, urogenital infection) the morphological changes, which consist of damage of biomembranes and change of immune homeostasis, are obvious in placenta tissues [2]. Lack of antioxidants for support of homeostasis in women with miscarriage leads to exhaustion of blood antioxidant protective system that, in its turn, causes significant increase of radical formation processes [4]. Object of the work – estimate the oxidative stress markers in women with pregnancy course complicated by miscarriage.