Features of the expression of the transcription factor NF-κB in experimental diabetes mellitus and administration of nonspecific blockers of TNFα

Abstract

Type I diabetes mellitus (T1D) is one of the most common non-communicable diseases in the world and is one of the three diseases (atherosclerosis, cancer and diabetes) that lead to disability. This pathology is considered as a multifactorial, polygenic autoimmune disease, in the development of which special attention should be paid to the relationship of gut-associated lymphoid tissue (GALT) and the factors that affect it and can potentiate the development of this pathology. [1]. Critical role may be played by changes in the expression of innate immune receptors by the structures of GALT - pattern-recognizing receptors (PRR), the main ligands for which are pathogen-associated molecular patterns (PAMP) of intestinal microorganisms [2].