Some aspects of synthesis 3- (2-florphenyl) -6-r1- [1,2,4] triazol [3,4-b] [1,3,4] thiadiazoleand 3- (2-, 3-ftorphenyl) - 6-r2-7h [1,2,4] triazolo [3,4-b] [1,3,4] tiadiazines

Abstract

Of particular note is the combination of 1,2,4-triazole with other structural fragments. The additional introduction of an amino group to the "structure" of fluorophenylderivatives 1,2,4-triazol-3-thiol and the production of a number of new substances on their basis can lead to the appearance of molecules with new types of biological activity. The aim of this work is synthesis and research of new substances of1,2,4-triazole with fluorophenyl derivatives, synthesize new 3- (2-fluorophenyl) -6-R1- [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazole and 3- (2-fluorophenyl, 3 -Fluorophenyl) -6-R2-7H [1,2,4] triazolo [3,4-b] [1,3,4] thiadiazines, in some cases, the passage of the cyclization reaction. Using the compound 5- (2-fluorophenyl) -4-amino-1,2,4-triazol-3-thiol, we first investigated the reaction of its cyclization in the presence of the corresponding aryl, heterocarboxylic acids in POCl3 medium.