Acute toxicity of 3-methyl- (1,3-dimethyl) -7-β-hydroxy-γ- aryloxypropylxanthinyl-8-thioacetic acid derivatives in experiment

Abstract

Recently, the urgency of the problem of atherosclerosis is only increasing, which is why the state of hyperlipidemia is called the «epidemic of the XXI century». Despite its high hypolipidemic effect, the statin group has a number of disadvantages associated with both economic feasibility for patients and significant side effects. A promising direction in this regard is the search for effective and low-toxic hypolipidemic agents, in particular on the basis of xanthine derivatives. In the study of future medicines, one of the key places is to study the complex of their toxicometric parameters, characterizing the degree of their toxicity and safety.