Дослідження ефірної олії трави Inula helenium L. флори України

Abstract

Досліджено кількісний вміст, фізико-хімічні властивості та хімічний склад ефірної олії трави Inula helenium L. флори України. Методом хромато-мас-спектрометрії ідентифіковано до 50 сполук (із них 37 вперше). Трава Inula helenium L. перспективна для одержання протимікробних і протизапальних лікарських засобів. The physical and chemical properties and composition of essential oil of Inula helenium L. herb to expand the resource base for drugs with expectorant and anti-inflammatory effects have been studied. The herb of Inula helenium L., which was harvested in 2010-2011 from different regions of Ukraine during flowering, has been examined. A content of essential oil has been estimated by the Clevenger apparatus. An identification and quantification of components was performed by gas chromatography-mass spectrometry. In I. helenium herb, harvested during flowering, a significant content of essential oil (up to (2.50 ± 0.03) %) has been estimated. High rates of acid, ether and ether number after acetylation in essential oil of I. helenium indicated the presence in it of free and bounded alcohols and acids, esters. In the essential oil of I. helenium have been identified up to 50 components, of which 37 have been identified the first time. Main compounds of the essential oil of I. helenium herb were: alantolactone ((34.28±3.12) %), thymol ((11.03±1.02) %), carvacrol ((7.25±0.72) %), eugenol ((6.57±0.55) %), isoalantolactone ((4.87±0.52) %), β-eudesmol ((2.00±0.22) %), cis-p-menth-2-en-1-ol ((1.64±0.14) %), pentacosane ((1.63±0.15) %), squalene ((1.26±0.11) %). The total content of compounds with antimicrobial effect (thymol and carvacrol) in the essential oil has been about up to 18.28 %. The total content of biological effective sesquiterpene lactones, which showed anti-inflammatory effects, in essential oil has been up to 41.49 %. The herb of I. helenium was a valuable raw herbal drug for the manufacturing of antimicrobial and antiinflammatory drugs.