Anxiolytic potential of 1-methyl/4-(tert-butyl)-2'-(cycloalkyl/hetaryl)-6'H-spiro[piperidine/cycloalkane-4,5'/1,5’-[1,2,4]triazolo[1,5-c]quinazolines]
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The aim of the work. Systematically analyze the binding affinities of a series of compounds targeting GABA(A) receptors, identify structural characteristics that correlate with high receptor binding efficiency, and develop structure-activity relationship (SAR) insights to guide future ligand design for pharmaceutical development.
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Antypenko L. Anxiolytic potential of 1-methyl/4-(tert-butyl)-2'-(cycloalkyl/hetaryl)-6'H-spiro[piperidine/cycloalkane-4,5'/1,5’-[1,2,4]triazolo[1,5-c]quinazolines] / L. Antypenko, K. Shabelnyk, O. Antypenko // Scientific forum: theory and practice of research : coll. of scientific papers “SCIENTIA” with Proc. of the VII Intern. Scientific and Theoretical Conf., Jan. 31, 2025. Valencia, Kingdom of Spain. - Valencia : International Center of Scientific Research, 2025. - P. 307-310. - https://doi.org/10.36074/scientia-31.01.2025.