Approaches to synthesis of ([1,2,4]triazolo[1,5-c]quinazolin-2-yl)benzoic acids as potential anti-inflammators

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are a common and diverse group of compounds that are mainly used to treat patients suffering from pain and inflammation (chronic pain, osteoarthritis, rheumatoid arthritis, postoperative surgical conditions, etc.) [1, 2]. In addition, this group of drugs is used as analgesics and antipyretics. Aryl carboxylic acids and their derivatives, which were among the first to be introduced into medical practice, are still important among NSAIDs [3]. In addition to the well-known salicylic and acetylsalicylic acids, this group of anti-inflammatory agents includes salts of salicylic acid, salsalate and diflunisal. Recently, representatives of anthranilic (2-aminobenzoic) acid derivatives have also been widely used, namely fenamates (mefenamic, meclofenamic, flufenamic and tolfenamic acids).