Current views for neuroprotective drug discovery

Abstract

The renewal of various nerve diseases and the emergence new pathologies urgently require a novel class of agents that are distinct than current therapeutic methods. Important advances in our understanding of the pathogenesis, and pathophysiology of wide variety of diseases have happened over the few decades. This underscores the need for a continued search for new biologically active compounds. In the design of new pharmaceutical agents, multiple factors need to be adjusted in parallel to discover the best balance of efficacy and safety. After many years of thorough medicinal chemistry investigations on the modification of well-known scaffolds, it is becoming increasingly hard to deliver new drug candidates.