Combination therapy of acne (acne vulgaris) in patients of different age groups

Abstract

Acne takes the lead among all skin diseases. According to epidemiological studies conducted in industrialized Western governments, the prevalence of acne development among adolescents ranges from 50% to 95%, depend-ing on kind of defeat. Acne is a disease that is most common in adolescents. First it appears in childhood after the start of the production of androgenic hormones by the sex glands and adrenal glands, and, stops usually after the period of adulting. However, it can continue to manifest in a significant part of adults, especially it is widespread by women [1, 10]. Acne is an androgen-dependent disease of hair follicles (or sebaceous hair formations). There are four main pathogenetic factors, the interaction of which contributes to the development of acne disease: the production of sebum by the sebaceous gland, changes in the process of keratinization, colonization of the follicles of Propioni-bacterium acnes, and the release of inflammatory mediators. Precise molecular level understanding of the acne development proves that acne is a disease that includes both innate and adaptive immune responses and inflammation.