Study of the structure of products of interaction between some naphthoquinone derivatives and pharmaceutical substances

Abstract

The purpose of the present work is to detail а study of the interaction between naphthoquinonebased analytical reagents and such pharmacologically active ingredients as acetylcysteine, β-alanine and taurine (2-aminoethanesulfonic acid) including the isolation and structure elucidation of the formed products. Material and Method: UV-visible spectrophotometry was applied to determine the stoichiometric coefficients of reactants in reactions between the pharmaceutical substances and naphthoquinone derivatives. 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used to prove the structure of the reaction products. Result and Discussion: The stoichiometric relationships of the reactants in the investigated medicinal substances reactions with quinone derivatives were determined by the methods of saturation and continuous changes. They are 1:1 in each case. According to the determined relationships of components reaction and optimal conditions for reactions path, the products of interaction of acetylcysteine with 2,3-dichloro-1,4-naphthoquinone and taurine, β-alanine with sodium 1,2-naphthoquinone-4-sulfonate were isolated and identified. In order to establish the structure of the compounds, the 1Н NMR-spectroscopy, IR spectroscopy, сhromatomass-spectrometry were used.