Clinical and Biochemical Efficiency of Neuroprotective Therapy in Patients with Chronic Cerebral Ischemia

Abstract

Objective: to evaluate the clinical and biochemical efficiency of Cortexin as to its impact on the activity of antioxidant enzymes, the content of the reduced forms of SS-SH system and cognitive functions in patients with chronic cerebral ischemia (CCI). Conclusions. The use of neuroprotective drug Cortexin for patients with CCI significantly improved their cognitive function, which was confirmed by a comprehensive neuropsychological testing. Cortexin course of treatment significantly affected the state of glutathione system, as in the plasma of patients and in hemolysate of erythrocytes.