Synthesis and physicochemical investigation of thiazoloxanthine derivatives

Abstract

ABSTRACT. Heterocycle containing compounds (xanthines, pyrazoles, thiazoles etc) represent very important structural units in drug discovery. In the design of new pharmaceutical agents, multiple factors need to be adjusted in parallel to discover the best balance of efficacy and safety. After many years of thorough medicinal chemistry investigations on the modification of well-known antibacterial scaffolds, it is becoming increasingly hard to deliver new leads. A survey of literature reveals the biological properties of these substances including hypoglycemic, anticancer, antioxidant, antiinflammatory, bronchodilator and xanthine oxidase inhibitory effects. In our opinion, combination of several heterocyclic systems in one molecule could improve pharmacological properties. Aim of our work was a development of method of thiazole and triazole containing xanthine derivative synthesis.