Dynamics and morphology of dendritic cells of the nasal submucosa of rats’ pharynx after antenatal antigen influence

Abstract

Researching determining mechanisms of structural and immunological homeostasis under physiological conditions, alteration of neurohumoral and metabolic control, consider to affirm that DCs are the most important modulators of skin and mucosal structure. Purpose of the study is to describe the dynamics and morphology of nasopharyngeal submucosa DCs in the postnatal period after the antenatal antigen action on fetus. DCs were detected on the cryostatum sections of the pharynx tissue using the Vahstein-Meisel method. DCs have high activity of ATPase. Results. It is settled that in all groups DCs number increases by 14 days of life, simultaneously with increasing of antigenic load on the body. In antigen-primed animals DCs activation take place earlier than in control, namely at the 7th day of life. In antigen-primed animals, the DCs number does not change, as compared to control, but the number of their dendrites is greater compared to control. DCs activation at 14th day of life is probably explained by an increased antigenic load on the body due to changing of the type of food. DCs high activity of ATPase is explained by activation of proteases in the endocytosis process of antigens. In conclusion, antenatal antigen influence does not cause changes in the ATP+ DCs number in nasopharyngeal submucosa, but in antigen-primed animals, the intensity of deposition of ATP+-material in the cytoplasm of the cells is higher and the number of dendrites in the cells is greater than that of the control and intact groups. In animals of all observed groups DCs activation passes at the first day after birth. In antigen-primed animals, the second wave of activation ATP+ DCs takes place at the 7th day of life, namely a week earlier than in animals of the intact group.