Salmonella-induced changes in immunoregulatory bacteria and the impact on transcriptional activity of the FOXP3 and roryt genes in rat GALT

Abstract

RATIONALE: Intestinal microbiome supports immune homeostasis. Segmental filamentousbacteria (SFB) induce differentiation of Th17-cells in enteric-associated lymphoid tissue (GALT). Clostridium (cluster IVand XIVa) and Bacteroidesfragilis (polysaccharide A) stimulate the formation of T-regulatory cells (Treg) and production of suppressor cytokine IL-10.

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Salmonella-induced changes in immunoregulatory bacteria and the impact on transcriptional activity of the FOXP3 and roryt genes in rat GALT / Yu. Bukina, A. Kamyshnyi, H. Koval, L. Fedoniuk, L. Dubuske // The Journal of allergy and clinical immunology. – 2020. – Volume 145, № 2. – P. 121.

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