Specifics of distribution of glycosaminoglycans in the white pulp of the spleen and stroma of rats after experimental modeling injection inside the fetus of antigens of different nature

Abstract

This work describes peculiarities of rat’s splenic white pulp and stromal elements structure attached to different terms after the birth normally and after intrauterine injection of antigens of different kinds. It’s established that intrauterine injection of antigens with different nature leads to quantitative changes in the accumulation of glycosaminoglycans low sulphated to 11 days of life, and high sulphated compounds on the first month of life, regardless of the antigen type, that may be a manifestation of qualitative imbalance in the formation of connective tissue in different functional zones of the rat’s spleen. The majority of these changes disappear up to 90th day after the birth.