Application of information technology in optimization of combined metabolitotropic cardioprotection

Abstract

Cardiovascular diseases are one of the most se-rious problems of modern medicine. Creation of combinations of metabolitotropic cardioprotec-tors selectively affecting individual target links of ischemic cascade of myocardial damage with the involvement of information technologies is a new promising approach. The aim of the study: to determine experimentally the approaches to the directed metabolic pharmacocorrection of ischemic myocardium and to develop the princi-ples of combined prescription of metabolito-tropic cardioprotectors on the basis of the creat-ed information technology of computer predic-tion. We have developed the basic theoretical concepts of a new scientific complex methodolo-gy with the involvement of information technol-ogies for the selection and creation of drug combinations of metabolitotropic agents with improved pharmacological and toxicological properties for metabolitotropic cardioprotec-tion. The obtained results were used in the de-velopment of an expert system for in silico sub-stantiation of rational combinations of metaboli-totropic drugs. The expert system was devel-oped in the form of web application. The ob-tained data became theoretical and experimental substantiation for the creation of combined drugs based on L-arginine, glycine, tryptophan, L-lysine. The application of new information technology in the targeted development of ra-tional combinations of metabolitotropic drugs will increase the efficiency of complex therapy of cardiovascular diseases of ischemic genesis.