Development and evaluation nitrendipine anoemulsion of intranasal delivery

Abstract

Introduction. Among anti-hypertensive drugs, no drug was discovered to affect directly on the brain with a greater efficiency level. In this article,we are going to know about a drug with higher efficiency to work on the brain directly. Subject. The purpose of the present investigation was to enhance the bioavailability of NDP through formulating a nanoemulsion for its intranasal delivery. A Caproyl 90® based nanoemulsion sytem with Tween 80 as the surfactant, Transcutol P® and Solutol HS-15® as solubiliser and cosurfactant respectively, was developed. It's a bicontinuous nanoemulsion, was identified in the pseudo-ternary phase diagrams,Tween 80: Transcutol P®: Solutol HS-15® at 1:2:1 weight ratio.