Synthesis And Bioactivity Of 5-Heteryl-1,2,4-Triazoles

Abstract

Despite the large number of publications devoted to the search for biologically active substances among derivatives of 1,2,4-triasole, scientific and technical literature and patents almost do not find information regarding the synthesis, physical, chemical and biological properties of S-derivatives of 4-R- 5- (thiophen-2-ylmethyl)-4H-1,2,4-triazoles. It is known that thiophene derivatives are used in agriculture for the synthesis of additives to oils and fuels, growth stimulators of plants and polymeric materials, and medical practice as drugs. The aim of this work was to analyze literary sources in order to identify the potential among derivatives of 5-heteryl-4H-1,2,4-triazole. Information search among literary data on the synthesis and biological activity of derivatives of 5-heteryl-1,2,4-triazole-3-thiol among the works of domestic and foreign scientists over the past decade. A review of literary sources on the synthesis and biological activity of derivatives of 5-heteryl-1,2,4-triazole-3-thiol. Based on the data found, the derivatives of 5-heteryl-1,2,4-triazole-3-thiol are promising compounds for the creation of new original drugs. Scientific-technical literature and patents have almost no information regarding the synthesis, physical, chemical, and biological properties of 4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles derivatives, therefore their study is relevant , has theoretical and practical significance.