Вплив тіолових антиоксидантів на вміст стрес-білка HSP70 у гіпокампі монгольських піщанок з гострою ішемією головного мозку

Abstract

In experiment on the model of acute cerebral ischemia was shown thiol antioxidants ability to influence on the stress-proteins HSP70 synthesis in hippocampus. Administration of the Tiotriasolin (50 mg/kg), Emoxipine (100 mg/kg), Mexidol (50 mg/kg) leads to the significant decrease of the cytotoxic marker of the oxide injury of the proteins – nitrotirosine, and to the increase of the HSP70 concentration. Comparative characteristics of the mentioned drugs showed statistically significant advantage of the Tiotriasolin.