Synthesis and physicochemical investigation of some thiazepino[3,4-f] purine-2,4(3H, 10H)-dione derivatives

Abstract

Ring systems are of great importance of bioorganic chemistry and consequently for the drug discovery procedures. Condensed moieties give molecules their basic form, determine their spatial conformation and keep substituents in their appropriate sites. In many biologically active structures, cyclic structures are directly involved in interactions with cell receptors, either through heteroatoms forming hydrogen bonds with appropriate protein residues or through hydrophobic interactions. The chemistry of the xanthine derivatives, 1H-purine-2,6-dione has been a subject of constant attention due to their importance in biology and medicine. Hence, xanthine derivatives are possessing pharmaceutical implementation in a variety of substances acting on various phases of human metabolism.