The pathogenetic role of pro- and anti- inflammatory cytokines in developing of diabetic myopathy in children

Abstract

The level of interleukin-6 and interleukin-13 was analysed in the blood serum of children with diabetes type 1 from 11 to 17 years old. They divided into three groups: the duration of diabetes less than 1 year (1st group), the duration of diabetes from 1 to 5 years (2nd group) and over 5 years (3rd group). The group of control includes conventionally healthy children. All kids have gone through the detailed clinical examination wich included functional tests to determine the condition of skeletal muscles, such as skeletal muscle strength, muscular tissue loss, functional capability and estimation of the muscular mass. Pathogeneticic mechanism of diabetic myopathy is a result of dysbalance between pro- and anti-inflammatory interleukins. The first manifestations of diabetic myopathy in children occur after the 5th year of diabetes, but subclinical signs develop over the first years of disease. It appears of muscle strength decrease and violation of its functional capability.