Features of the cytokine type in the regulation of the immune response in women with functional ovarian cysts on the background of type 2 diabetes mellitus

Abstract

The aim of the work was to reveal the features of the cytokine type in the regulation of the immune response in women with functional ovarian cysts on the background of type 2 diabetes mellitus. A total of 104 patients of reproductive age with functional ovarian cysts and type 2 diabetes mellitus were examined in the Department of Gynecology in the limited liability company “VITACENTER”. A general clinical examination, a study of the immune status and a bacteriological study of the vaginal discharge were carried out. In the spectrum of microorganisms isolated from the vagina, Gram- and Gram+ bacteria, Candida albicans were present. In patients with infertility and nulliparity, a decrease in the functional activity of neutrophils at the digestion stage was noted. The index of the phagocytic number of neutrophils indicated incompleteness of phagocytosis against the background of the depleted functional-metabolic reserve and the parameters of the bactericidal system were reduced. In women giving birth, the functional activity of neutrophils did not change; there was a decrease in digestive capacity against the background of the preserved functional metabolic reserve. In the group of nulliparous women, a Th2/Th1 type of immune response with a predominance of Th 2 type was observed. In patients with infertility, a Th1/Th2 type of immune response was observed with a predominance of the Th1 type. In the group of women giving birth, a Th2-type of immune response was observed. The change in the state of the vaginal microbiocenosis leads to the formation of dysfunction of the immune system, particularly the cytokine type of regulation. Patients with different parity have differences in the cytokine type regulation of the immune response.