Morphological Features of Liver Reactivity After Intranatal Antigen Influence

Abstract

In experimental animals after antenatal administration of staphylococcal toxoid, the relative area occupied by hepatic plates (as in the control) tends to increase gradually during the first two weeks of life. In animals, which were exposed to antenatal Staphy-lococcal purified liquid toxoid administration, the number of lymphocytes in the central zone of the liver lobule is lower than in the intact and control groups on the first day is 1.04 ± 0.35 cells on unit area. (2.26 ± 0.52 cells on unit area in control). The maximum decrease in the number of lymphocytes in the central zone in experimental rats in contrast to the control occurs on the 30th day of life together with a simultaneous decrease in the number of Kupffer macrophages and is 0.70 ± 0.35 cells on unit area - in the experiment (2.61 ± 0.69 cells on unit area in the control group). A decrease in the number of lymphocytes is observed also in the peripheral zone of the lobule compared with the control from the third to the 30th day of life, but such changes have no statistical significance. It was found that RCA+ receptors are expressed on dendritic cells in the liver, the number of RCA+ dendritic cells changes in waves during the first three months after birth. The relative mass of the liver in experimental group rats significantly exceeds the control at the seventh day of life (3.06 ± 0.05% in the experimental and 2.91 ± 0.02% in the control group). In experimental rats the number of dendritic cells decreases during the first two weeks of life, the minimum number is observed on the 3rd day. In the peripheral zone of the lobule, a decrease in the number of dendritic cells is observed on the 1st and the 21st day of postnatal life in comparison with control.