Cytokines profile (IL-4, IL-13) of children with severe forms of atopic dermatitis versus other grades of severity

Abstract

Atopic dermatitis (AD), or atopic eczema, is chronic recurrent inflammatory skin disease that often manifests in the first year of life and affects up to 12-20% of children [6, 9]. It’s prevalence is steadily increasing worldwide. Development of skin inflammatory process in patients with AD is caused by a complex interactions of genetic mechanisms, environmental factors, infectious agents, skin barrier defects and immune mechanisms [3].