Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity
| dc.contributor.author | Voskoboynik, O. Y. | |
| dc.contributor.author | Kovalenko, S. I. | |
| dc.contributor.author | Shishkina, S. V. | |
| dc.contributor.author | Воскобойнік, Олексій Юрійович | |
| dc.contributor.author | Коваленко, Сергій Іванович | |
| dc.contributor.author | Шишкіна, Світлана В. | |
| dc.date.accessioned | 2016-12-15T21:55:38Z | |
| dc.date.available | 2016-12-15T21:55:38Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | The synthesis and antitumor activity of substituted benzo[e] 1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones – novel electroeficient tricyclic compounds – are described. These compounds were prepared by treatment of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with sodium nitrite in acetic acid. Spectral properties of synthesized compounds were studied and compared with spectral data of known 3-R-8-R1-10-R2-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones. These compounds are promising antitumor agents. The most active anticancer compound 3d was studied in dose-depended anticancer activity assay and its selective growth inhibition against breast cancer MDA-MB-468 cell line was established (GI50 = 0.41 μm) | uk_UK |
| dc.description.sponsorship | The authors gratefully acknowledge the Enamine Ltd. (Kiev, Ukraine) for financial support of this work, and team of the Drug Synthesis and Chemistry Branch, National Cancer Institute, Bethesda, MD, USA, for in vitro evaluation of anticancer activity. | uk_UK |
| dc.identifier.citation | Voskoboynik O. Y. Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity / O. Y. Voskoboynik, S. I. Kovalenko, S. V. Shishkina // Heterocyclic Communications – 2016. – Vol. 22, Issue 3. – P. 137-141. DOI 10.1515/hc-2015-0190 | uk_UK |
| dc.identifier.other | DOI 10.1515/hc-2015-0190 | |
| dc.identifier.uri | https://zsmu.rosbai.com/handle/123456789/5098 | |
| dc.language.iso | en | uk_UK |
| dc.subject | anticancer activity | uk_UK |
| dc.subject | benzo[e][1,2,4]triazino[2,3- c][1,2,3]triazines | uk_UK |
| dc.subject | heterocyclic compounds | uk_UK |
| dc.title | Benzo[e][1,2,4]triazino[2,3-c][1,2,3]triazin-2-ones electro-deficient heterocyclic compounds with promising anticancer activity | uk_UK |
| dc.type | Article | uk_UK |
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