Structure-activity relationship of 5,6-dihydro-tetrazolo[1,5-c]quinazolines targeting Candida glabrata
| dc.contributor.author | Antypenko, L. | |
| dc.contributor.author | Antypenko, O. M. | |
| dc.contributor.author | Vasilieva, I. | |
| dc.contributor.author | Kozyrieva, V. | |
| dc.contributor.author | Антипенко, Олексій Миколайович | |
| dc.date.accessioned | 2024-06-11T07:40:41Z | |
| dc.date.available | 2024-06-11T07:40:41Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Candida species cause both disseminated and superficial fungal infections in humans. Although azole antifungals have historically proven effective in treating such infections, recent epidemiological studies highlight a crucial concern in the clinical context. Some Candida species exhibit inherent resistance to azoles and echinocandins, and the emergence of high-level resistance poses a significant problem. Consequently, derivatives of 5,6-dihydrotetrazolo[1,5-c]quinazolines have shown potent inhibitory properties against C. glabrata at concentrations range of 0.4 – 55.0 μM, leading to the identification of a structure-activity relationship. | uk_UK |
| dc.identifier.citation | Structure-activity relationship of 5,6-dihydro-tetrazolo[1,5-c]quinazolines targeting Candida glabrata / L. Antypenko, O. Antypenko, I. Vasilieva, V. Kozyrieva // Grail of Science : proc. of the VII Intern. Scie. and Practical Conf. "Scientific researches and methods of their carrying out: world experience and domestic realities", 15 Mar. 2024, Vinnytsia, UKR-Vienna, AUT (Online). - Vinnytsia, 2024. - N 37. - С. 474-477. - https://doi.org/10.36074/grail-of-science.15.03.2024.080. | uk_UK |
| dc.identifier.uri | https://zsmu.rosbai.com/handle/123456789/20707 | |
| dc.language.iso | en | uk_UK |
| dc.subject | antifungal activity | uk_UK |
| dc.subject | C. glabrata | uk_UK |
| dc.subject | 5,6-dihydrotetrazolo[1,5-c]quinazolines | uk_UK |
| dc.subject | structure-activity relationship | uk_UK |
| dc.title | Structure-activity relationship of 5,6-dihydro-tetrazolo[1,5-c]quinazolines targeting Candida glabrata | uk_UK |
| dc.type | Article | uk_UK |