Design, synthesis and anticonvulsant activity of new diacylthiosemicarbazides

Abstract

The modification products of the carboxyl group of alkyl- and cycloalkylcarboxylic acids (amides, carbamates, semicarbazides, etc.) are one of the promising classes of organic compounds in terms of searching for anticonvulsants [1-3, 7-14]. Firstly, these structural fragments are present in most molecules of both approved for use and experimental anticonvulsant drugs [1, 2]. Secondly, such modification has been studied on valproic acid and is promising, in view of the teratogenicity and hepatotoxicity reduction and a positive epileptogenic effect [3].