Comparative morphofunctional analysis of chronic hyperglycemia influence on pancreatic islets in spontaneous hypertensive and Wistar rats

Abstract

The rapidly increasing incidence and prevalence of dyslipidemia, obesity and type 2 diabetes mellitus (DM) are becoming a major global health issue in industrialized countries, however, the need for identification of relevant molecular targets and devising effective preventive and therapeutic algorithms is met by only modest advancement of our knowledge. Systemic arterial hypertension (AH) and DM represent two important risk factors for cardiovascular disease, the leading cause of morbidity and mortality in the world. The coexistence of AH and diabetes is commonly observed in adults and has been associated with a higher risk of cardiovascular events. These two conditions often coexist and have in common the metabolic features of hyperinsulinemia and glucose intolerance. In fact, both are considered as disorders of insulin resistance.