Diuretic activity of 4-(furan-2-ylmethylenamino)-1-alkyl-4h-1,2,4-triazole halides

Abstract

Topicality. Diuretic agents play an important role in the treatment of a number of diseases (arterial hypertension, chronic heart failure, and ascites in cirrhosis, acute and chronic renal failure, and other.) [1, 3, 4]. But a significant number of them does not always satisfy the needs of modern medicine [2]. First of all, this is due to the side effect that these drugs can display. Therefore, the search for new biologically active substances that improve the functional activity of the kidneys is one of the urgent problems of experimental pharmacology and corresponds to the strategy of modern pharmaceutical science [3]. According to literature data, nitrogen-containing heterocyclic compounds, such as 1,2,4-triazole derivatives [1, 3, 4] has deserve considerable attention to the study of diuretic activity. The aim of the study was to experimentally investigate the effect of 3,5-R-4H-amino-R1-1,2,4-triazole on the functional activity of the kidneys and discuss the relationship of the “structure-action” with the iodide derivative halides.