Synthesis and research of the impact of new derivatives of 4-R-3-(morpholinomethyl)-4H-1, 2, 4-triazole-5-thiol on cultural attributes of pathogenic М. Bovis

Abstract

Synthesis and research of the impact of new derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol on cultural attributes of pathogenic М. bovis. Problematics of collateral impact of xenobiotics and counteraction to their toxic influence continues to be extremely significant. Resistant tuberculosis is a serious problem of health defense of population in many developing countries. Treatment of such form of tuberculosis takes more time and demands more and more expensive medicines. The aim of this work is synthesis and research of new derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiols and their ability of influencing cultural attributes of pathogenic М. bovis. The object of research is new derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiols. Cultivation of pathogenic strains of М. bovis was carried out at the temperature of 37°С in the environment of рН 6,5 and 7,1, where synthesized compounds were additionally placed in mass concentrations of 0,1; 0,5; 1%. As a comparative substance a classical suberculosis-static preparation isoniazid was used. As a result of the research held is was concluded that the most pronounced tuberculosis-static influence among compounds under analysis had N'-(2-((4-amino-3-(morpholinomethyl)-4H-1,2,4-triazol-5-yl)thio)acetyl)isonicotinohydrazide hydrobromide. Promising application of further research of synthesized substances as anti-tuberculosis means was demonstrated.