Synthesis, transformation and biological properties of S-derivatives of 4-amino-5-(5-R-pyrazol-3-yl)-1,2,4-triazole-3-thiol

Abstract

The main goal of the work is to study the potential of 1,2,4-triazole derivatives as a source of new drug candidates with improved safety and efficacy profiles. The research is aimed at the synthesis and characterization of a number of S-derivatives of 4-amino-5-(5-R-pyrazol-3-yl)-1,2,4- triazol-3-thiol, as well as at the evaluation of their physicochemical properties and biological functions.