Pharmacological modulation of heat shock protein 70 (HSP70) - dependent mechanisms of endogenous neuroprotection in conditions of prenatal chronic alcoholism by cerebrocurin and tiocetam

Abstract

Objective: One of the primary reactions of the genome in response to stress is different genesis induction of heat shock proteins – HSP. The purpose of this study was to investigate the concentration of heat shock protein (HSP70) and hypoxia-inducible factor (HIF-1) in the brain of rats undergoing chronic prenatal alcoholism in different periods of ischemia and define the role of these proteins in the implementation of neuroprotective effect of Cerebrocurin and Tiocetam.