Molecularly-biochemical and neuropsychophysiological aspects of neuroprotective activity of mexidol during chronic immobilizational stress

Abstract

Abstract: It is found out that in models of rats’ chronic stress an oral administration of Mexidol (100 mg/kg) during 10 days decreases a degree of DNA oxidative modification markers (8-OHG), proteins APH and KPH, hyperproduction of NO, and activity of NO-synthase. Also it changes an expression of early gene c-Fos and increases a concentration of Bcl-2 in neurons of paraventricular nuclei of the hypothalamus.