Synthesis and Biological Activity of 8-Benzylidenehydrazino-3-Methyl-7-β-Methoxyethylxanthines

Abstract

A simple preparative synthesis of 8-hydrazino-3-methyl-7--methoxyethylxanthine was developed. Reaction of the obtained hydrazinoxanthine with aldehydes and ketones produced several previously undescribed 8-ylidenehydrazino derivatives of 3-methyl-7--methoxyethylxanthine. PMR spectroscopy confirmed the structures of the synthesized compounds. Biological tests established that several of the synthesized compounds had pronounced antimicrobial, antifungal, and antioxidant activity and could be recommended for further research.