Expression of HSP70 in the brain of rats during experimental cerebral ischemia modeling and on the background of neuroprotection

Abstract

Experimental research has found that acute cerebral ischemia modeling in rats is accompanied by a significant increase in the main marker of oxidative degradation of proteins – nitrotyrosine beginning from the first day of the experiment. Concurrently there has been a decline in stress-protein HSP70 in brain tissue. Administration of Cerebrocurin for 4 days has led to a decrease in the levels of nitrotyrosine, as well as to increase in the expression of stress-responsive protein HSP70 in the acute period of cerebral ischemia.