Synthesis of 5-R-4-R1-3-alkylthio-1,2,4-triazoles and study influence of their adsorption ability on the results of toxicity and anti-hypoxic activity

Abstract

During our research of biologically active substances we have synthesized series of new 5-R-4-R1-3-alkylthio-1,2,4- triazoles for original drugs creation. 14 new compounds have been synthesized in total. The structure of it has been confirmed by a complex of modern physical and chemical methods of analysis. For these compounds the data of toxicity, anti-hypoxic activity, surface activity and adsorption ability has been set. The obtained results of biological activity have been compared with data of adsorption properties of 1,2,4-triazoles derivatives to establish structureaction regularity.